Technology
LSPR vs SPR: Pros and Cons
September 2026
Nanoparticle and thin-film plasmonic sensing compared: sensing depth, bulk sensitivity, optics, reproducibility, and which suits your assay.
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Technology
Lensless SPR: How It Works
September 2026
Why conventional SPR needs complex optics, and how lensless SPR keeps the Kretschmann configuration while streamlining everything around it.
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Drug Discovery
SPR on the Road: A Day at Merck
SPR on the Road · September 2026
First stop in our field series: we brought the portable P4SPR to Merck's New Jersey campus for real-time antibody characterization in biomanufacturing — and heard the same thing we heard at GSK. Everyone knows what they'd do with in-facility SPR data during a run.
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Technology
Ask Dr. Live
September 2026
Your binding questions, answered by a man with a doctorate and no patience for the price of a mass spectrometer. SPR talk, one question at a time.
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Biosensing
From DNA Probes to Wearable Biosensors: How SPR Accelerates the Pipeline
April 2026
Four recent studies trace the full arc from rational DNA probe design to a wearable device monitoring insulin in a living animal — with SPR at every step.
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Clinical & Diagnostics
Real-time monitoring of vancomycin using a split-aptamer surface plasmon resonance biosensor
November 2025
A new split-aptamer SPR biosensor enables real-time, label-free monitoring of vancomycin — a critical antibiotic where therapeutic drug monitoring can mean the difference between efficacy and toxicity.
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Technology
SPR Sensorgram Explained
Updated September 2026
The sensorgram is the core output of every SPR experiment. Learn the five phases of a binding cycle and what kinetic and affinity data you can extract from each.
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Technology
Cheat sheet: Static and Kinetic SPR
November 2025
A quick-reference guide to the two core SPR measurement modes — when to use each, what data you get, and how to interpret the results.
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Technology
Manual Injection vs Pump-Assisted SPR Experiment
Updated September 2026
Steady-state or kinetic? The choice of injection mode determines what data you get. A clear breakdown of manual vs. pump-assisted SPR — when to use each and how to interpret the results.
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Methods & Protocols
Easy SPR experiment set-up: the Affinité sensor difference
April 2024
Setting up an SPR experiment shouldn't require a surface chemistry PhD. Here's how Affinité sensors make the process straightforward from day one.
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Methods & Protocols
How you can calibrate your SPR measurement
June 2022
Calibration is the foundation of reliable SPR data. This guide walks through the calibration procedure using NaCl solutions and what to expect from a well-calibrated system.
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Drug Discovery
Integrating SPR into AAV Production Pipeline
June 2022
AAV-based gene therapies require rigorous characterization at every production step. SPR provides real-time binding data that fits naturally into the bioproduction workflow.
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Methods & Protocols
How a true Portable SPR can revolutionize your R&D workflow
March 2022
Portability changes what's possible in the lab — and in the field. A look at what true portability means for SPR and why it matters for modern research workflows.
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Methods & Protocols
The Advantages of a Portable SPR Instrument
September 2020
How portable SPR compares to large commercial systems — flexibility, modularity, on-site testing, and real-world applications from field detection to drug discovery.
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Clinical & Diagnostics
Evaluation of a Novel Vaccine Platform by Using Portable SPR
January 2022
Portable SPR proved its value in evaluating a novel vaccine platform — demonstrating that high-quality binding data doesn't require a fixed benchtop instrument.
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Drug Discovery
Rapid Quality Control of Antibodies Using P4SPR™
September 2020
Comparing binding performance across four antibody sources in under 2 hours — no ELISA required. A demonstration of portable SPR for fast biopharmaceutical QC.
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Methods & Protocols
Using Portable SPR to Speed Up Your Lateral Flow Assay Development
December 2021
Lateral flow assays are fast to deploy but slow to develop. SPR accelerates the critical early steps — antibody selection, affinity ranking, and surface optimization.
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Biosensing
Measuring Heparin Binding with SPR: The SARS-CoV-2 Spike Study
Updated September 2026
How to build a heparin surface, which controls to run, why salt didn't regenerate it, and how a competition assay showed which sulfates the spike protein needs.
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Biosensing
Measuring Binding Affinity with SPR: Protein-Protein Interactions
Updated September 2026
How tightly do two proteins bind, and how fast do they let go? Kinetic vs steady-state KD, assay design, and what bad data looks like.
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Methods & Protocols
Afficoat™ for Reducing Non-Specific Adsorption in SPR Experiments
September 2021
Non-specific adsorption is one of the most common sources of unreliable SPR data. Afficoat — Affinité's proprietary surface chemistry — addresses this problem at the molecular level.
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Methods & Protocols
Surface Plasmon Resonance: Advantages and Disadvantages
September 2021 · Updated September 2026
What SPR does well, where it falls short, and how to work around each limitation — plus when another technique is the better choice.
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Clinical & Diagnostics
SPR to Examine Cross-Reactivity of Antibodies with SARS-CoV-2 Spike Proteins
July 2021
As SARS-CoV-2 variants emerged, SPR provided critical real-time data on how antibody cross-reactivity with native and variant spike proteins changes — with direct implications for vaccine strategy.
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Clinical & Diagnostics
SPR Platform Based on Ionic Liquids for Breast Cancer Biomarker Detection
June 2021
A novel SPR sensor surface based on ionic liquids enables detection of a breast cancer biomarker directly in cell lysates — demonstrating the power of surface chemistry innovation.
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Biosensing
SPR for Enriching Synthetic Biology Research
May 2021
Synthetic biology depends on understanding how engineered molecules interact. SPR brings quantitative binding data to the design-build-test cycle.
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Biosensing
Portable SPR for On-Site Testing of Environmental Contaminants
May 2021
Environmental contaminant testing traditionally requires samples to be sent to a lab. Portable SPR changes that — bringing real-time detection to the field.
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Clinical & Diagnostics
The Ability of SPR Compared to BLI to Detect PSA in Human Serum
March 2021
A direct comparison of SPR and bio-layer interferometry (BLI) for prostate-specific antigen detection in human serum — with implications for which technology best suits clinical biosensing.
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Biosensing
Detection of Liposomes by Surface Plasmon Resonance
December 2020
Liposomes are central to drug delivery and membrane biology research. SPR provides a powerful label-free method for characterizing liposome binding and membrane interactions.
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Clinical & Diagnostics
SPR vs ELISA: Differences and When to Use Each
November 2020 · Updated September 2026
Label-free and real-time vs endpoint and enzyme-amplified: how SPR and ELISA differ, what each measures, and when ELISA is still the better choice.
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